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Twenty to One Cream

Natural Menopause Relief

Bioidentical combination cream for the relief
of hot flushes, weight gain and other symptoms of menopause *
A cream for women deficient in progesterone and oestrogen *

Twenty to One Cream

Natural Menopause Relief

Bioidentical combination cream for the relief of hot flushes, weight gain and other symptoms of menopause

Natural Progesterone and Oestrogen Combination Cream

Wellsprings Twenty to One combination cream is a natural alternative to Hormone Replacement Therapy (HRT) for women deficient in progesterone and oestrogen.

Some menopausal women may find that they are unable to completely eliminate hot flushes, mood swings or vaginal dryness using a bioidentical progesterone cream like Wellsprings Serenity, so an additional small amount of oestrogen is required.

Wellsprings Twenty to One cream (also known as '20-1') contains bioidentical progesterone and oestrogen in a ratio of 20 to 1, hence the name *
Effective Symptom Relief
Including hot flushes, night sweats, bloating, breast tenderness, low libido, vaginal dryness, mood problems, insomnia, headaches, hair loss and dry skin.*
Natural, Bioidentical Hormones
The active ingredients in Wellsprings Twenty to One are bioidentical progesterone and oestrogen which are identical to your body’s own hormones. *
Tried and Tested
Wellsprings' creams have been helping relieve the symptoms of menopause for thousands of women since 1997. *

Why a Cream?

In pill form bioidentical hormones can be filtered out by the liver, so Twenty to One is a hyper-liposomal cream which optimises progesterone and oestrogen absorption and maximises symptom relief.
What doctors say about Wellsprings...
Dr Tony Coope
"Wellsprings have the required knowledge, integrity and quality products to improve the health and hormonal balance of women along their whole 'continuum of vulnerability' from puberty to post-menopause."
Dr B Peatfield
"I have been using natural progesterone cream for some years now... both my patients and I have, without exception, been delighted with its efficacy."

What our customers say about 20-1 combination cream...
Lynda, London
"After a couple of months on 20-1 cream I'm a different person. I am nearly a stone lighter, the hot sweats have all but gone and I can now get on with my life" *
Jacqui, Bedford
"After using Wellsprings 20-1 for one week the hot flushes eased. You have saved my life and my relationship with my children and partner. I can't rave enough about this product" *

* Please note that our customer reviews are individual experiences. Your results may vary.

What the science says about natural progesterone...
There is a large amount of high quality scientific research showing that bioidentical progesterone can relieve menopause symptoms and promote general health in women. It has also been shown to be safer than the synthetic progestins used in common HRT treatments.
"Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms... The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins."
"[progesterone] has been shown to relieve menopausal symptoms and improve sleep without affecting cognition, blood lipids or cardiovascular risk factors. It may also reduce bone loss and maintain skin elasticity”
"[transdermal progesterone and estrogen] are a safe and well-tolerated option to treat menopausal symptoms, with a better benefit risk profile compared to synthetic gestagens”
"In vitro studies of human osteoblasts in culture, prospective studies in adolescent, premenopausal, perimenopausal, and postmenopausal women all indicate that progesterone — likely working through bone formation pathways — plays an active role in maintaining women's bone and in osteoporosis prevention”
   60ml jar lasts 2+ months   100ml bottle lasts 4+ months
60ml jar lasts 2+ months
100ml bottle lasts 4+ months

A Premium Combination Cream

Wellsprings 20-1 Cream is a gentle, fragrance free, natural progesterone and oestrogen cream with an advanced liposomal formula that optimises absorption.

Certified Bioidentical Hormone Content

2.34% Natural Progesterone + 0.12% Natural Oestrogen
Each 60ml (2.1oz) jar of 20-1 cream contains 1,404mg of bioidentical USP Pharmaceutical grade Natural Progesterone + 60mg of Natural Estriol + 6mg of Estradiol (Estriol 0.11%, Estradiol 0.01%)

Advanced Liposomal Formula

Enhanced Absorption
Wellsprings 20-1's advanced liposomal formula optimises progesterone absorption while keeping skin looking healthy and moisturised in areas where applied.


All natural ingredients
Free from common allergens.

Fragrance Free

For discreet application
Wellsprings 20-1 is fragrance free so as not to interfere with other scented products you may be using.

Animal Friendly

No animal testing
Wellsprings 20-1 is not tested on animals in any way and no animal by-products are used in its formulation.


Deionized Water, Aloe Barbadensis Leaf Juice, Soybean Oil, Progesterone (2.34%), Glycerin, Glyceryl Stearate SE, Isopropyl Myristate , Phenoxyethanol, Caprylyl Glycol , Sorbic Acid, Cetyl Alcohol, Methyl Glucose Sesquistearate, Stearic Acid, Sodium PCA, Sodium, Hyaluronate, Tocopheryl Acetate, Carbomer, PEG-20 Methyl Glucose Sesquistearate, Grapefruit Seed Extract, Xanthan Gum, Estriol (0.11%), Aminomethylpropanol, Estradiol (0.01%).
   60ml jar lasts 2+ months   100ml bottle lasts 4+ months
60ml jar lasts 2+ months
100ml bottle lasts 4+ months
A dose of Wellsprings 20-1 cream should be applied morning and bedtime to thin tissue areas of the body. It is important to massage the cream into a different area each time.

Each recommended dose of cream is 1/8th of a teaspoon (0.5ml). This amount is the size of a garden pea.

We recommend using a double dosage (2 pea-sized amounts of cream, twice a day) for the first month of application. Also, please ensure you finish the full jar or pump bottle of your cream to allow time for your hormone levels to stabilise and symptoms to be properly treated.

Whether you choose our 60ml jar or 100ml pump bottle, the dosage is exactly the same. To dispense a pea-sized amount from the pump bottle, gently press the pump until the correct amount is dispensed.*

Usage Schedule *
Usage Schedule *
* Typical usage for best performance based on experience of long-term users of 20-1. Your results may vary.

Usage Overview

A healthy woman will naturally manufacture 20-25mg of progesterone per day in the second half of her monthly cycle and the intention is to deliver this same amount of bioidentical progesterone into the system via the cream.

Each dose of 20-1 contains 12mg of bioidentical progesterone, so one application in the morning and one at bedtime will constitute a dosage of 24mg per day, delivering approximately the same as would be produced naturally.

If symptoms are severe you may use a double dose mornings and evenings. However, dosage should be assessed and modified by each individual through their own experience over a period of time.

Each 60ml jar contains around 120 pea-sized doses, so a jar will last around 4 months for those on the pre-menopausal regime and around 10 weeks for those on the 24 day menopausal regime.

Our 100ml pump bottle contains around 200 pea-sized doses, so a bottle will last around 7 months for those on the pre-menopausal regime and around 4 months for those on the 24 day menopausal regime.*

Applying Cream
20-1 should be applied to thin tissue areas of the body, rotating between different areas each day.

The best application areas are: the face, neck, inside of the upper arms, lower back and inner thighs.

Top Tip

How to measure a single dose
Simply dab the underside of your little finger halfway to the nail if using a jar, or gently press the pump if using our pump bottle. The amount should be about the size of a garden pea.
* Every woman is unique. Your results may vary

What is the difference between Wellsprings 20-1 and Wellsprings Serenity?
Wellsprings 20-1 is the same formula as Wellsprings Serenity with the addition of two natural oestrogen hormones, Estriol 0.11%, Estradiol 0.01%. The natural progesterone content remains at 2.34%.
Can I use Wellsprings 20-1 at the same time as Wellsprings Serenity?
Generally you need to use only one product. However, some women find that they need a very small amount of oestrogen so they use Serenity once daily and 20-1 once daily, instead of using the same cream twice daily. Both creams have the same progesterone content, but 20-1 has the addition of two natural oestrogens. *
Should I use Wellsprings 20-1 instead of Wellsprings Serenity?
A small proportion of menopausal women may find they are unable to completely eliminate hot flushes, night sweats or vaginal dryness using natural progesterone cream alone.

Any or all of these symptoms persisting can be signs of oestrogen deficiency, particularly after a hysterectomy. In most cases, when progesterone levels are right, the body has the raw materials to produce oestrogen, however in a small number of cases the body does not produce the oestrogen and it is for just such cases that we have formulated our 20-1 Cream.

It'll depend on your symptoms, and their severity, as to which cream you need. 20-1 cream contains a mixture of both progesterone and oestrogen in the ratio of 20-1 and is a completely natural hormone replacement cream suitable for women who have been on HRT, or had a hysterectomy. Click here to see a side-by-side comparison of the two creams *
Can I use Wellsprings creams alongside the contraceptive coil or pill?
If you're using these just to help with heavy bleeding then simultaneous use with your cream is fine. However, if you're using them for contraception, then no we CANNOT recommend it, unless you also take additional precautions.

The coil and pill both contain synthetic progestins which compete with the same receptor sites in the body as the natural progesterone in our creams to make both less effective.
   60ml jar lasts 2+ months   100ml bottle lasts 4+ months
60ml jar lasts 2+ months
100ml bottle lasts 4+ months
Hormonal changes during menopause may encourage weight gain.
Find out what causes this common symptom, and how to get relief
Hear what doctors have to say about natural progesterone and its benefits
Discover the natural alternative to hormone replacement therapy
Natural progesterone can be an effective treatment for this serious condition
What happens to hormones at menopause and how can symptoms be treated?
Understand what's behind the increased incidence of oestrogen dominance in the western world
Learn about the condition behind menopause symptoms
How can a cream deliver progesterone into the body?
What are bioidentical hormones and why are the relevant to your health
How do progesterone creams work and where did they come from
Wellsprings offers two varieties of natural progesterone cream. Read on to find out which is best for you
Despite claims to the contrary, Yam Extract does NOT contain progesterone or raise progesterone levels in the body

All information given on this site is for general interest only. Every woman is unique. Your results may vary.
Serenity Cream Questions
of Wellsprings creams
* Please note that our customer reviews are individual experiences. Your results may vary.
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