Natural Products
Customer Reviews
Hormone Learning
Wellsprings Store

Serenity Cream

Natural Menopause Relief

Bioidentical progesterone cream for menopause relief *
Bioidentical progesterone cream for menopause relief *

Serenity Natural Progesterone Cream

For over 20 years Wellsprings Serenity cream has been chosen by women and doctors as a natural alternative to Hormone Replacement Therapy (HRT).

Many women who use Serenity report that their menopause symptoms are relieved and quality of life improved, without the side-effects often experienced with common HRT treatments. *
Effective Symptoms Relief
Wellsprings Serenity can help relieve most menopausal symptoms.

These include hot flushes, night sweats, bloating, weight gain, breast tenderness, low libido, vaginal dryness, mood problems, insomnia, headaches, hair loss and dry skin. *
Tried and Tested
Wellsprings Serenity has been helping relieve the symptoms of menopause for thousands of women since 1997.

Natural Progesterone, its active ingredient, has been prescribed since the 1930's for the treatment of hormone imbalance. *
Natural, Bioidentical Hormones
The active ingredient in Wellsprings Serenity is Natural Progesterone which is bioidentical to your body’s own progesterone.

Conventional HRT uses synthetic hormones that are alien to the body and believed by some to be behind its reported side-effects. *
Long Term Health
The Natural Progesterone in Wellsprings Serenity may combat the effects of bone breakdown that accelerate during menopause and can lead to osteopenia and osteoporosis. *
* Every woman is unique. Your results may vary.

What doctors say about natural progesterone cream...
Dame Dr Shirley Bond
"I had never been keen to give my patients traditional HRT and now I had a safe product to use to help them deal with their problems and balance their hormones."
Dr B Peatfield
"I have been using natural progesterone cream for some years now... both my patients and I have, without exception, been delighted with its efficacy."

What our customers say about Serenity natural progesterone cream...
Christine, Cambs
"The flushes have reduced... My weight is slowly coming back down...
I can’t recommend this product enough, Thank you Serenity."
Jane, Surrey
"My anxiety and hot flushes have gone. I lost 7 pounds in weight in 10 days. I’m high on life and feel and look wonderful." *
MW, South Shields
"I have been using this cream for 3 months... I am absolutely thrilled with the results. The hot flushes and night sweats have completely gone." *

* Please note that our customer reviews are individual experiences. Your results may vary.


A Premium Progesterone Cream

Wellsprings Serenity is a gentle, fragrance free, natural progesterone cream with an advanced liposomal formula that optimises absorption.

Certified Bioidentical Progesterone Content

2.34% Natural Progesterone
Each 60g (2.1oz) jar of Serenity contains 1,404mg of bioidentical USP Pharmaceutical grade Natural Progesterone extracted from plant saponins.

Advanced Liposomal Formula

Enhanced Absorption
Serenity’s advanced liposomal formula optimises progesterone absorption while keeping skin looking healthy and moisturised in areas where applied.


All natural ingredients
Free from common allergens.

Fragrance Free

For discreet application
Serenity is fragrance free so as not to interfere with other scented products you may be using.

Animal Friendly

No animal testing
Serenity is not tested on animals in any way and no animal by-products are used in its formulation.


Deionized Water, Caprylic/Capric Triglyceride, Glycerin, Aloe Barbadensis Leaf Juice, Progesterone, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Cetyl Alcohol, Glyceryl Stearate, Isopropyl Myristate, Stearic Acid, Sodium, Hyaluronate, Sodium PCA, Methyl Glucose Sesquistearate, Aminomethyl Propanol, Carbomer, Tocopheryl Acetate, Grapefruit Seed Extract, PEG-20 Methyl Glucose Sesquistearate, Xanthan Gum. Manufactured in the USA
A dose of Wellsprings Serenity cream should be applied morning and bedtime to both thin and fatty tissue areas of the body. It is important to massage the cream into a different area each time.

Each recommended dose of cream is 1/8th of a teaspoon (0.5ml). This amount is the size of a garden pea.

We recommend using a double dosage (2 pea-sized amounts of cream, twice a day) for the first month of application. Also, please ensure you finish the full jar or bottle of your cream to allow time for your hormone levels to stabilise and symptoms to be properly treated.

Whether you choose our 60ml jar or 100ml pump bottle, the doseage is exactly the same. To dispense a pea-sized amount from the pump bottle, gently press the pump until the correct amount is dispensed.*

Usage Schedule *
* Typical usage for best performance based on experience of long-term users of Serenity. Your results may vary.

Usage Overview

A healthy woman will naturally manufacture 20-25mg of progesterone per day in the second half of her monthly cycle and the intention is to deliver this same amount of bioidentical progesterone into the system via the cream.

Each dose of Serenity contains 12mg of bioidentical progesterone, so one application in the morning and one at bedtime will constitute a dosage of 24mg per day, delivering approximately the same as would be produced naturally.

If symptoms are severe you may use a double dose mornings and evenings, but all women are different and dosage should be assessed and modified by each individual through their own experience over a period of time.

Each 60ml jar contains 120 doses, so a jar will last around 4 months for those on the pre-menopausal regime and 2.5 months for those on the 24 day menopausal regime.*

Applying Cream

Serenity should be applied to both thin and fatty tissue areas of the body.

The best application areas are: the face, neck, inside of the upper arms, lower back or inner thighs for thin skinned areas and buttocks, lower arms, outer thighs and stomach for fatty areas.

Top Tip

How to measure a single dose
Simply dab the underside of your little finger halfway to the nail if using a jar, or gently press the pump if using our pump bottle. The amount should be about the size of a garden pea.

Top Tip

Quick Relief
For a more instant effect (for migraine headaches for example) it has been found that massaging a little extra cream into the areas of thin skin (inner wrists, temples and behind the ears) may give relief.
* Every woman is unique. Your results may vary
Why hasn't my doctor prescribed natural progesterone?
Natural progesterone has in fact been prescribed since the 1930s and a growing number of doctors are now recommending it.

The major pharmaceutical companies market HRT treatments that contain artificial hormones that they can patent and are profitable. The resources of these companies has enabled them to position them as the standard prescription for menopause symptoms and other conditions of hormonal imbalance despite increasing reports of their side effects. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone

What is Oestrogen Dominance?
What are the conditions natural progesterone can benefit?
Natural progesterone is most commonly used to treat both short and long term symptoms associated with Oestrogen Dominance.

During menopause these symptoms include:

- Hot flushes
- Mood Swings & Depression
- Water retention
- Breast swelling and pain
- Heavy or irregular periods
- Uterine fibroids
- Weight gain, particularly around hips and thighs

One of the prime long term conditions associated with oestrogen dominance is osteoporosis. Natural Progesterone can be an effective treatment for this condition. *

Relevant articles:

What is Oestrogen Dominance?

Natural Progesterone

Osteoporosis & Natural Progesterone
What is natural progesterone?
Natural progesterone, also known as bioidentical progesterone, is 100% the same as the progesterone hormone produced naturally in the body. As such it is treated by the body the same way and can perform all the functions of the body's own progesterone.

Prescribed since the 1930s, it is used to treat menopause related symptoms and other conditions associated with hormone imbalance.

It is important to recognise the difference between natural progesterone and the artificial progesterones (progestins) used in common HRT treatments. While in some ways progestins perform in the same manner as natural progesterone they are in fact chemically different and thus not treated by the body the same way. This is believed to be behind the reported side effects of common HRT treatments. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone

What is Oestrogen Dominance?
Why does Serenity contain just progesterone and no oestrogen?
Specialists have identified that a deficiency in progesterone in relation to oestrogen is at the root of most women's hormonal complaints.

Doctors such as Dr John R Lee, who prescribed natural progesterone for 30 years and wrote extensively about its benefits, demonstrated that supplementing progesterone alone, in its natural form, is what most sufferers require in order for health and wellbeing to be restored. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone

What is Oestrogen Dominance?
Are there any side effects associated with natural progesterone?
There have been no reported side effects associated with natural progesterone since it was first prescribed, over 60 years ago. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone
How can a cream get natural progesterone into my body?
'Transdermal application' is the method of delivering substances into the body through the skin. It is used in products such as nicotine patches and pain-killing gels.

When taken orally, natural progesterone gets removed almost entirely by the liver. When applied in cream form over 90% of the progesterone content is absorbed. *

Relevant articles:

Transdermal Creams - How they work and why

Doctors and Natural Progesterone
What is the difference between Serenity and conventional HRT treatments?
Most conventional HRT treatments prescribed to treat progesterone deficiency employ chemically modified, artificial progesterones known as progestins. While performing in some ways like natural progesterone, these substances are alien to the body and not treated the same way. This is believed to be behind the reported side effects of conventional HRT treatments. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone
How long does a jar of Serenity last?
With regular use a jar of Serenity should last around 3 months.
What is the natural progesterone content of Wellsprings Serenity?
Wellsprings Serenity has a natural progesterone content of 1,404mg per 60g (2.1oz) jar. That is equivalent to 2.34%.
Is there medical research behind the claims for natural progesterone?
Yes, there is a lot of research indicating a positive role for natural progesterone in alleviating menopause symptoms, and the negative side-effects of synthetic HRT. You can read some of these citations here and here*
Can I use Wellsprings creams alongside the contraceptive coil or pill?
If you're using these just to help with heavy bleeding then simultaneous use with your cream is fine. However, if you're using them for contraception, then no we CANNOT recommend it, unless you also take additional precautions.

The coil and pill both contain synthetic progestins which compete with the same receptor sites in the body as the natural progesterone in our creams to make both less effective.

* Every woman is unique. Your results may vary

Hormonal changes during menopause may encourage weight gain.
Hear what doctors have to say about natural progesterone and its benefits
Discover the natural alternative to hormone replacement therapy
Natural progesterone can be an effective treatment for this serious condition
What happens to hormones at menopause and how can symptoms be treated?
Understand what's behind the increased incidence of oestrogen dominance in the western world
Learn about the condition behind menopause symptoms
How can a cream deliver progesterone into the body?
What are bioidentical hormones and why are the relevant to your health
How do progesterone creams work and where did they come from
Wellsprings offers two varieties of natural progesterone cream. Read on to find out which is best for you
Oestrogen dominance can interfere with thyroid hormone activity
Despite claims to the contrary, Yam Extract does NOT contain progesterone or raise progesterone levels in the body

All information given on this site is for general interest only. Every woman is unique. Your results may vary.
Serenity Cream Questions
of Wellsprings creams
* Please note that our customer reviews are individual experiences. Your results may vary.