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Serenity Cream

Natural Menopause Relief

Bioidentical progesterone cream for the relief of hot flushes, weight gain and other symptoms of menopause *

Serenity Cream

Natural Menopause Relief

Bioidentical progesterone cream for the relief of hot flushes, weight gain and other symptoms of menopause

Natural Progesterone Cream

For over 25 years Wellsprings Serenity cream has been chosen by women and doctors as a natural alternative to Hormone Replacement Therapy (HRT).

Many women who use Serenity report that their menopause symptoms are relieved and quality of life improved, without the side-effects often experienced with common HRT treatments. *
Effective Menopause Symptom Relief
Including hot flushes, night sweats, bloating, weight gain, low libido, vaginal dryness, brain fog, mood problems, insomnia and headaches.*
Natural, Bioidentical Hormones
The active ingredient in Wellsprings Serenity is natural progesterone which is bioidentical to your body’s own progesterone. *
Tried and Tested
Wellsprings Serenity has been helping relieve the symptoms of menopause for thousands of women since 1997. *

How Serenity Works

Oestrogen and progesterone are the two dominant reproductive hormones in women. At menopause their levels start to drop, but commonly progesterone levels fall much faster, creating a hormone imbalance known as oestrogen dominance.
Oestrogen dominance has been linked to many menopause symptoms including hot flushes, night sweats, weight gain and mood problems.
What doctors say about natural progesterone cream...
Dame Dr Shirley Bond
"I had never been keen to give my patients traditional HRT and now I had a safe product to use to help them deal with their problems and balance their hormones."
Dr B Peatfield
"I have been using natural progesterone cream for some years now... both my patients and I have, without exception, been delighted with its efficacy."

What our customers say about Serenity natural progesterone cream...
Christine, Cambs
"The flushes have reduced... My weight is slowly coming back down... I can’t recommend this product enough, Thank you Serenity." *
Jane, Surrey
"My anxiety and hot flushes have gone. I lost 7 pounds in weight in 10 days. I’m high on life and feel and look wonderful." *
GB, Doncaster
"I have been using Serenity cream for three months... I feel healthy and energetic and symptoms are less severe each month." *

* Please note that our customer reviews are individual experiences. Your results may vary.

What the science says about natural progesterone...
There is a large amount of high quality scientific research showing that bioidentical progesterone can relieve menopause symptoms and promote general health in women. It has also been shown to be safer than the synthetic progestins used in common HRT treatments.
"Bioidentical hormone preparations have demonstrated effectiveness in addressing menopausal symptoms... The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins."
"[progesterone] has been shown to relieve menopausal symptoms and improve sleep without affecting cognition, blood lipids or cardiovascular risk factors. It may also reduce bone loss and maintain skin elasticity"
"[transdermal progesterone and estrogen] are a safe and well-tolerated option to treat menopausal symptoms, with a better benefit risk profile compared to synthetic gestagens"

Why Bioidentical Progesterone?

Unlike some HRT products, Wellsprings Serenity replenishes your body with progesterone that is bioidentical to that produced in the body naturally, restoring hormone balance and relieving the symptoms of oestrogen dominance and menopause.

Why a Cream?

In pill form bioidentical progesterone is filtered out by the liver, reducing effectiveness and potentially causing a number of side effects. Skin application is known to be most effective for hormone absorption and Serenity is a hyper-liposomal cream which optimises progesterone uptake and maximises symptom relief.

A Premium Progesterone Cream

Wellsprings Serenity is a gentle, fragrance free, natural progesterone cream with an advanced liposomal formula that optimises absorption.

Certified Bioidentical Progesterone Content

2.34% Natural Progesterone
Each 60ml (2.1oz) jar of Serenity contains 1,404mg of bioidentical USP Pharmaceutical grade Natural Progesterone extracted from plant saponins.

Advanced Liposomal Formula

Enhanced Absorption
Serenity’s advanced liposomal formula optimises progesterone absorption while keeping skin looking healthy and moisturised in areas where applied.


All natural ingredients
Free from common allergens.

Fragrance Free

For discreet application
Serenity is fragrance free so as not to interfere with other scented products you may be using.

Animal Friendly

No animal testing
Serenity is not tested on animals in any way and no animal by-products are used in its formulation.


Deionized Water, Caprylic/Capric Triglyceride, Glycerin, Aloe Barbadensis Leaf Juice, Progesterone, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid, Cetyl Alcohol, Glyceryl Stearate, Isopropyl Myristate, Stearic Acid, Sodium, Hyaluronate, Sodium PCA, Methyl Glucose Sesquistearate, Aminomethyl Propanol, Carbomer, Tocopheryl Acetate, Grapefruit Seed Extract, PEG-20 Methyl Glucose Sesquistearate, Xanthan Gum.
Manufactured in the USA
A dose of Wellsprings Serenity cream should be applied morning and evening to thin tissue areas of the body. It is important to gently rub the cream into a different area each time.

Each recommended dose of cream is 1/8th of a teaspoon (0.5ml). This amount is the size of a garden pea.

We recommend using a double dosage (2 pea-sized amounts of cream, twice a day) for the first month of application. Also, please ensure you finish the full jar or pump bottle of your cream to allow time for your hormone levels to stabilise and symptoms to be properly treated.

Whether you choose our 60ml jar or 100ml pump bottle, the dosage is exactly the same. To dispense a pea-sized amount from the pump bottle, gently press the pump until the correct amount is dispensed.*

Usage Schedule *
Usage Schedule *
* Typical usage for best performance based on experience of long-term users of Serenity. Your results may vary.

Usage Overview

A healthy woman will naturally manufacture 20-25mg of progesterone per day in the second half of her monthly cycle and the intention is to deliver this same amount of bioidentical progesterone into the system via the cream.

Each dose of Serenity contains 12mg of bioidentical progesterone, so one application in the morning and one in the evening will constitute a dosage of 24mg per day, delivering approximately the same as would be produced naturally.

If symptoms are severe you may use a double dose mornings and evenings, but all women are different and dosage should be assessed and modified by each individual through their own experience over a period of time.

Each 60ml jar contains around 120 pea-sized doses, so a jar will last around four months.

Our 100ml pump bottle contains around 200 pea-sized doses, so a bottle will last around seven months.*


Applying Cream

Serenity should be applied to thin tissue areas of the body, rotating between different areas each day.

The best application areas are: the face, neck, inside of the upper arms, lower back and inner thighs.

Top Tip

Top Tips
How to measure a single dose
Simply dab the underside of your little finger halfway to the nail if using a jar, or gently press the pump if using our pump bottle. The amount should be about the size of a garden pea.

Top Tip

Quick Relief
For a more instant effect (for migraine headaches for example) it has been found that massaging a little extra cream into the areas of thin skin (inner wrists, temples and behind the ears) may give relief.
* Every woman is unique. Your results may vary
Why hasn't my doctor prescribed natural progesterone?
Natural progesterone has in fact been prescribed since the 1930s and a growing number of doctors are now recommending it.

The major pharmaceutical companies market HRT treatments that contain artificial hormones that they can patent and are profitable. The resources of these companies has enabled them to position them as the standard prescription for menopause symptoms and other conditions of hormonal imbalance despite increasing reports of their side effects. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone

What is Oestrogen Dominance?
What are the conditions that natural progesterone can benefit?
Natural progesterone is most commonly used to treat both short and long term symptoms associated with Oestrogen Dominance.

During menopause these symptoms include:

- Hot flushes
- Night Sweats
- Brain fog
- Mood swings & depression
- Water retention
- Breast swelling and pain
- Heavy or irregular periods
- Uterine fibroids
- Weight gain, particularly around hips and thighs

One of the prime long term conditions associated with oestrogen dominance is osteoporosis. Natural Progesterone can be an effective treatment for this condition. *

Relevant articles:

What is Oestrogen Dominance?

Natural Progesterone

Osteoporosis & Natural Progesterone
What is natural progesterone?
Natural progesterone, also known as bioidentical progesterone, is 100% the same as the progesterone hormone produced naturally in the body. As such it is treated by the body the same way and can perform all the functions of the body's own progesterone.

Prescribed since the 1930s, it is used to treat menopause related symptoms and other conditions associated with hormone imbalance.

It is important to recognise the difference between natural progesterone and the artificial progesterones (progestins) used in common HRT treatments. While in some ways progestins perform in the same manner as natural progesterone they are in fact chemically different and thus not treated by the body the same way. This is believed to be behind the reported side effects of common HRT treatments. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone

What is Oestrogen Dominance?
Why does Serenity contain just progesterone and no oestrogen?
Specialists have identified that a deficiency in progesterone in relation to oestrogen is at the root of most women's hormonal complaints.

Doctors such as Dr John R Lee, who prescribed natural progesterone for 30 years and wrote extensively about its benefits, demonstrated that supplementing progesterone alone, in its natural form, is what most sufferers require in order for health and wellbeing to be restored. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone

What is Oestrogen Dominance?
Are there any side effects associated with natural progesterone?
There have been no reported side effects associated with natural progesterone since it was first prescribed, over 60 years ago. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone
How can a cream get natural progesterone into my body?
'Transdermal application' is the method of delivering substances into the body through the skin. It is used in products such as nicotine patches and pain-killing gels.

When taken orally, natural progesterone gets removed almost entirely by the liver. When applied in cream form over 90% of the progesterone content is absorbed. *

Relevant articles:

Transdermal Creams - How they work and why

Doctors and Natural Progesterone
What is the difference between Serenity and conventional HRT treatments?
Most conventional HRT treatments prescribed to treat progesterone deficiency employ chemically modified, artificial progesterones known as progestins. While performing in some ways like natural progesterone, these substances are alien to the body and not treated the same way. This is believed to be behind the reported side effects of conventional HRT treatments. *

Relevant articles:

Natural Progesterone

Doctors and Natural Progesterone
How long does a jar of Serenity last?
Each 60ml jar contains around 120 pea-sized doses, so a 60ml jar will last around four months for those on the pre-menopausal regime and around ten weeks for those on the 24 day menopausal regime. Our 100ml pump bottle contains around 200 pea-sized doses, so a bottle will last around seven months for those on the pre-menopausal regime and around four months for those on the 24 day menopausal regime.
What is the natural progesterone content of Wellsprings Serenity?
Wellsprings Serenity has a natural progesterone content of 1,404mg per 60ml (2.1oz) jar, which is equivalent to 2.34%.
Is there medical research behind the claims for natural progesterone?
Yes, there is a lot of research indicating a positive role for natural progesterone in alleviating menopause symptoms, and the negative side-effects of synthetic HRT. You can read some of these citations here and here*
Can I use Wellsprings creams alongside the contraceptive coil or pill?
If you're using these just to help with heavy bleeding then simultaneous use with your cream is fine. However, if you're using them for contraception, then no we CANNOT recommend it, unless you also take additional precautions.

The coil and pill both contain synthetic progestins which compete with the same receptor sites in the body as the natural progesterone in our creams to make both less effective.

* Every woman is unique. Your results may vary

Hormonal changes during menopause may encourage weight gain.
Find out what causes this common symptom, and how to get relief
Hear what doctors have to say about natural progesterone and its benefits
Discover the natural alternative to hormone replacement therapy
Natural progesterone can be an effective treatment for this serious condition
What happens to hormones at menopause and how can symptoms be treated?
Understand what's behind the increased incidence of oestrogen dominance in the western world
Learn about the condition behind menopause symptoms
How can a cream deliver progesterone into the body?
What are bioidentical hormones and why are the relevant to your health
How do progesterone creams work and where did they come from
Wellsprings offers two varieties of natural progesterone cream. Read on to find out which is best for you
Oestrogen dominance can interfere with thyroid hormone activity
Despite claims to the contrary, Yam Extract does NOT contain progesterone or raise progesterone levels in the body

All information given on this site is for general interest only. Every woman is unique. Your results may vary.
Serenity Cream Questions
of Wellsprings creams
* Please note that our customer reviews are individual experiences. Your results may vary.
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