Wellsprings offers a range of bioidentical hormone creams, each formulated for a different need:
Serenity – natural progesterone only (2.34%); our most popular cream and the ideal starting point.
Twenty to One (also known as '20-1') – the same progesterone plus 0.12% natural oestrogens, for stronger combined relief.
Balancing Cream – natural oestrogen (estriol) only, to add or boost oestrogen, often used alongside a progesterone cream.
Lifelong Care Cream – progesterone and oestrogen at lower, long-term doses, enriched with magnesium, zinc and vitamin D, for everyday wellness beyond the menopause.
For most women, and especially for those getting started with bioidentical hormones, we recommend Serenity cream. Check the comparison chart below to find out which cream is best for you.
PLEASE NOTE: If you have a medical history where oestrogen is inadvisable then as a precaution we suggest you use Serenity rather than Twenty to One, Balancing or Lifelong Care cream.
Serenity – natural progesterone only (2.34%); our most popular cream and the ideal starting point.
Twenty to One (also known as '20-1') – the same progesterone plus 0.12% natural oestrogens, for stronger combined relief.
Balancing Cream – natural oestrogen (estriol) only, to add or boost oestrogen, often used alongside a progesterone cream.
Lifelong Care Cream – progesterone and oestrogen at lower, long-term doses, enriched with magnesium, zinc and vitamin D, for everyday wellness beyond the menopause.
For most women, and especially for those getting started with bioidentical hormones, we recommend Serenity cream. Check the comparison chart below to find out which cream is best for you.
| Serenity Cream |
20-1 Cream |
Balancing Cream |
Lifelong Care Cream |
|
| This is your first time trying bioidentical hormones | ![]() |
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| You're experiencing classic menopausal symptoms such as hot flushes/night sweats, mood swings and sleep problems | ![]() |
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| You're suffering from menopause-related weight gain | ![]() |
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| You've found that Serenity cream does not adequately control your menopause symptoms | ![]() |
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| You've previously been on HRT | ![]() |
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| You're suffering from menopause-related anxiety and depression | ![]() |
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| You have vaginal dryness or atrophy | ![]() |
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| You've had a hysterectomy | ![]() |
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| You want to add extra oestrogen to your existing progesterone cream | ![]() |
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| You're past the menopause and want ongoing hormone support for long-term heart, bone and brain health | ![]() |
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| You'd like a daily cream enriched with magnesium, zinc and vitamin D | ![]() |
PLEASE NOTE: If you have a medical history where oestrogen is inadvisable then as a precaution we suggest you use Serenity rather than Twenty to One, Balancing or Lifelong Care cream.
Medical Disclaimer
This information is for general informational purposes only and is not intended as medical advice. It should not be used to diagnose or treat any health condition. Always consult your doctor or qualified healthcare professional before starting any new treatment or making changes to your existing care. Every woman is unique and individual results may vary.
This information is for general informational purposes only and is not intended as medical advice. It should not be used to diagnose or treat any health condition. Always consult your doctor or qualified healthcare professional before starting any new treatment or making changes to your existing care. Every woman is unique and individual results may vary.
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All information given on this site is for general interest only. Every woman is unique. Your results may vary.





















